News/Blog

June 30, 2016

Anti-aging component to be tested on humans

Nicotinamide mononucleotide, or NMN, a substance produced in our bodies and also present in food will be tested on human subjects after it showed significant results in animal models.  The mechanism considered to result in anti-aging properties is the activating of a gene called sirtuin.  Sirtuins are able to inhibit certain genes, including ones that promote aging. When animals were administered NMN, it was found that the compound can reverse age-related eyesight and metabolism deteriorations, improve diabetes and slow down aging.  The new study will be conducted at Keio University and Washington University in St. Louis.

NMN is currently available as a supplement but no current indication for anti-aging effects can be claimed.

http://www.postguam.com/the_globe/philippines_asia/clinical-trial-set-for-anti-aging-compound/article_581ce3d0-386b-11e6-b1c8-af3f28ffcd8f.html

May 27, 2016

Polymer "skin" replicates younger skin

Olivo labs developed a crosslinked polymer layer that can be applied to the skin making it look younger, tighter and also can increase hydration as well as absorption of medication applied on skin. The new material is called XPL.

The researchers at the company announced that "the skin-conforming silicone-based polymer has the mechanical properties matching that of youthful skin while enabling additional designs in other properties such as serving as a barrier protection to minimize water loss, creating opportunities in both the aesthetic and medical markets, particularly in the area of drug delivery."

http://dx.doi.org/10.1038/nmat4635

The study was published on Nature Materials website.  Authors include:  Betty Yu, former Vice President at Living Proof; Robert Langer, Institute Professor, MIT; Daniel Anderson, Associate Professor, MIT; Rox Anderson, MGH; Barbara Gilchrest, MGH; Fernanda Sakamoto, MGH; Soo-Young Kang, Living Proof; Morgan Pilkenton and Alpesh Patel formerly of Living Proof; and Ariya Akthakul, Nithin Ramadurai, and Amir Nashat of Olivo Laboratories.

May 18, 2016

Latest thoughts on Alzheimer's disease....

Is there an infectious component?  Can one get the disease from infected surgical instruments?                                                                    http://www.bbc.com/news/health-34184470

Theory of an over-reactive immune system as a cause for dementia.                                                                                                       http://medicalxpress.com/news/2016-05-rethink-dementia.html

Yoga and meditation can help mild cognitive impairment.                                                                                                          http://www.medicalnewstoday.com/articles/310148.php

Implanted device containing cells genetically engineered to produce antibodies that recognize and target amyloid-β in Alzheimer's disease showing promising results                                                                                                                                                                                https://www.sciencedaily.com/releases/2016/03/160317105447.htm

May 12, 2016

Higher levels of Vitamin D linked to lower cancer risk

A new study correlates blood levels of Vitamin D over 40 ng/ml with a decrease risk of cancer.  The marker of vitamin D used in the study was 25-hydroxyvitamin D, which is the main form in the blood.  It appears that the overall level of cancer risk is reduced by higher levels of Vitamin D.

Vitamin D can be administered in different forms: tablet, capsule, liquid and intravenous.  The daily dose needs to be adjusted to individual needs and titrated against the blood levels.

Sharon L. McDonnell, Carole Baggerly, Christine B. French, Leo L. Baggerly, Cedric F. Garland, Edward D. Gorham, Joan M. Lappe, Robert P. Heaney. Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study. PLOS ONE, 2016; 11 (4): e0152441 DOI: 10.1371/journal.pone.0152441

May 5, 2016

Supplement shown to reverse aging of organs

A new study shows that NR (nicotinamide riboside) which is a precursor of NAD+, which can be ingested as a supplement has stopped and reversed the aging of muscles in aging mice.  Researchers wanted to reactivate the stem cells in the muscle by targeting molecules that help the mitochondria function properly.  Mitochondria is the power generator of the cell and slowing down its function is usually associated with aging/degeneration processes. The stem cells are able to regenerate/repair tissue and organs by producing new, healthy cells.  It is believed that the NR effect of helping the mitochondria work better and therefore help the stem cells kick back into action is not limited to the muscle tissue but it can help any other tissue/organs.  It also might be able to help with tissue repair following injury or with degenerative processes that affect even young people.

So far, there is no negative effect associated with the administration of NR, even at high doses but further studies are warranted.

Hongbo Zhang, Dongryeol Ryu, Yibo Wu, Karim Gariani, Xu Wang, Peiling Luan, Davide D’amico, Eduardo R. Ropelle, Matthias P. Lutolf, Ruedi Aebersold, Kristina Schoonjans, Keir J. Menzies, Johan Auwerx. NAD repletion improves mitochondrial and stem cell function and enhances lifespan in mice.

Science, 2016 DOI: 10.1126/science.aaf2693    https://www.sciencedaily.com/releases/2016/04/160428152124.htm

May 3, 2016

Antibacterial soap exposes health workers to high triclosan levels due to hand washing

Julia K. MacIsaac, Roy R. Gerona, Paul D. Blanc, Latifat Apatira, Matthew W. Friesen, Michael Coppolino, Sarah Janssen. Health Care Worker Exposures to the Antibacterial Agent Triclosan. Journal of Occupational and Environmental Medicine, 2014; 56 (8): 834 DOI: 10.1097/JOM.0000000000000183

October 14, 2015

Elevated saliva cortisol levels in the evening associated with loss of brain mass and cognitive deficits

It is unclear if the elevated cortisol has a causative effect for the changes in brain mass and decrease cognitive function or is simply associated with these changes.  However, a high evening saliva cortisol level should trigger further investigation of cognitive function and a plan to help maintain the brain function in this area.

Ask us how you can measure your saliva cortisol levels which are also helpful in moitoring the daily cortisol curve and adrenal function.  Adrenal fatigue can be easily treated with often dramatic improvements in the quality of life.

Geerlings MI, Sigurdsson S, Eiriksdottir G, Garcia ME, Harris TB, Gudnason V, Launer LJ.  “Salivary cortisol, brain volumes, and cognition in community-dwelling elderly without dementia.”  Neurology. 2015 Aug 19. pii: 10.1212/WNL.0000000000001931

October 13, 2015

GABA might help planning and prioritizing complex actions (multi-tasking)

GABA (gamma aminobutyric acid) is an amino acid and is the predominant inhibitory neurotransmitter in the central nervous system.  GABA supplements and compounded supplements have been used to help with anxiety and sleep difficulties.

This study suggest another, important role of the brain pathways controlled by GABA, this time in selecting actions involved in complex tasks.

The study authors conclude that: "These findings, involving the systemic administration of synthetic GABA, provide the first evidence for a possible causal role of the GABA-ergic system in modulating performance in action cascading.”

Steenbergen L, Sellaro R, Stock AK, Beste C, Colzato LS. “[Gamma]-Aminobutyric acid (GABA) administration improves action selection processes: a randomized controlled trial.”  Sci Rep. 2015 Jul 31;5:12770.

October 9, 2015

Leucine could help build muscle mass, might help prevent muscle loss associated with aging

A new study shows that the amino acid leucine could help with protein synthesis, reducing the risk of muscle loss (sarcopenia).

Zhe-rong Xu, Zhong-ju Tan, Qin Zhang, Qi-feng Gui, Yun-mei Yang.  “The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis.”  British Journal of Nutrition, Jan. 2015, 25-34.

October 6, 2015

Large study shows Echinacea is as effective in treating early flu as Tamiflu

Previous studies showed that using Echinacea cuts down the chances of getting a cold, especially when taken with Vitamin C or can reduce the length of the symptoms.

The current study goes further and compares the herbal remedy to Tamiflu.

Please check out our IV therapy section for ways to help you avoid a cold or get quickly over your symptoms and return to feeling healthy.

http://www.nutraingredients-usa.com/Research/Significant-Large-trial-supports-echinacea-s-immune-benefits

October 2, 2015

Boost your beta-alanine levels to increase muscle strength

Fast-twitch muscles have a higher concentration of carnosine which supports the muscle by the way of lactic acid buffering.  This in turn could decrease the muscle pain and fatigue allowing for bursts of speed or simply ability to exercise longer. 

This effect was demonstrated in younger cyclists or sprinters but also in older (60-80 year old) subjects.  As we age, the muscle mass decreases and with it the amount of carnosine in the fast-twitch muscle.

The dietary source of carnosine is animal meat but also cheese, eggs and milk.  Canosine is cleaved by the enzyme carnosinase into alanine and histidine causing only a limited amount to reach the muscles.  For vegetarians, eating avocado, beans, bran, brewer’s yeast, brown rice, corn, legumes, mushrooms, nuts, seeds, watercress, whole grains and spirulina would supply the alanine and histidine needed for the body to manufacture carnosine, right at the muscle level.  Supplementation with beta-alanine also can increase the muscle carnosine level by combining with histidine at muscle level.

Other potential benefits of carnosine are:

-anti-oxidant

-speeds up cell replacement

-chelates metals in the body

-protects the heart and blood vessels

-protects kidneys

-can help prevent cataracts

-can help stomach ulcers

-neuro-protective

-improve skin complexion

September 25, 2015

Balance your Vitamin D to keep your memory

New study shows that low vitamin D is associated with dementia. One more reason to check your levels and get adequte replacement of Vitamin D. 

http://archneur.jamanetwork.com/article.aspx?articleid=2436596

June 18, 2015

FDA banning the use of Trans Fats

Some would say that this decision should have been made decades ago but finally the Food and Drug Administration ruled that partially hydrogenated oils – the primary source of artificial trans fats in processed foods – are no longer generally recognized as safe for use in food.  Food companies have three years – until June 18, 2018 – to remove them from products. 

The uses of trans fats are improving taste, hold artificial colors and make foods last longer. At the same time they have been linked to heart disease, and the Center for Science in the Public Interest says they cause about 50,000 fatal heart attacks each year. They can also raise the levels of harmful LDL cholesterol.

Dr. Georges Benjamin, executive director of the American Public Health Association, explained in a statement that the estimated economic benefits of banning partially hydrogenated oils over 20 years would be between $117 billion and $242 billion which totally outweighs the projected costs of switching to healthier oils, which would total between $12 billion and $14 billion, not to mention a healthier, longer life for consumers.

June 11, 2015

Can diet help migraines?

A study published in February 2015 found that a lower dietary folate intake correlates with higher migraine episodes frequency.

According to the Migraine Research Foundation, approximately 18% of women and 6% of men have migraines. Migraines also tend to run in families so if one parent suffers from migraines, there is a 40% chance a child will also suffer.  If both parents have migraines, the chance is as high as 90% for the children to have migraines.

The study authors concluded, "The results from this study indicate that folate intake in the form of folic acid may influence migraine frequency in female migraine with aura sufferers."

Reference:

Menon S, et al. Headache. 2015; 55:301-9.

You can check your folate level with a blood test.  In addition there are blood tests that help understand if the folate is appropriately metabolized by your body and if you need a specific form of folate for supplementation.

May 27, 2015

Probiotics….good for more than gut flora balancing?

A new study shows that probiotics can help with insulin resistance, linked to developing type II diabetes.

The study published in February 2015 Hulston CJ, et al. Br J Nutr. 2015;113:596-602 concluded that "These results suggest that probiotic supplementation may be useful in the prevention of diet-induced metabolic diseases such as type 2 diabetes."

The study showed that taking probiotics, in this case Lactobacillus casei, resulted in the body tolerating even a diet high in fat and energy without a decrease in insulin sensitivity and therefore without an increase in blood sugar levels.

These results are exciting but since the study only looked at one week of overeating, it likely needs further research looking at a longer period of time and larger group of subjects.

Balancing the intestinal bacteria has many important roles.  You can start with a commonly used probiotic but if not getting the desired results you might need to have a test of your stool to identify your imbalances, you can then supplement with a formula that is specific to your needs.

There is no clear consensus on when to take the probiotics but generally it is believed it is best to take it first thing in the morning.

May 26, 2015

Magnesium….how to measure it and how to replace it? 

Magnesium is an essential micronutrient, it is involved in hundreds of metabolic reactions, helping support bone health, as well as nerve and muscle function.

Dietary sources of magnesium are fruits, green leafy vegetables, whole grains, nuts and dairy products. The estimated average requirement (EAR) for magnesium is 330-350 mg/day for men and 225-265 mg/day for women, even though this could increase under certain conditions. The 2010 Dietary Guidelines, and more recently the 2015 Dietary Guidelines Advisory Committee Report, indicate that often the magnesium intake is insufficient.

Magnesium also plays a major role in the metabolism of glucose.   A research team led by Yanni Papanikolaou (France) analyzed data collected on subjects enrolled in the US National Health and Nutrition Examination Survey (NHANES), 2001-2010.  Adults with adequate intake of magnesium had significantly different HOMA-IR (a measure of insulin resistance), systolic blood pressure, and HDL-cholesterol, as compared to subjects with inadequate intake of magnesium.  Adequate intake of magnesium also showed significant differences in waist circumference (associated with metabolic syndrome).  The team found that a higher dietary intake of magnesium was associated with significantly reduced odds of elevated glycohemoglobin (indicative of high blood sugar), metabolic syndrome, overweight or obesity, elevated blood pressure, reduced HDL  (good cholesterol).

Often magnesium levels are measured in serum but they are most accurate when measured as RBC-magnesium (red blood cell magnesium).  For diet supplementation there are many available forms of magnesium and a few are better absorbed and some have higher available elemental magnesium (not the salt of magnesium).  Magnesium could also be administered IV as part of IV therapy supplementation, in a Vitamin and Mineral Supplementation formula.

For certain conditions magnesium is used as a topical cream that can help with muscle relaxation/pain, cramps and muscle spasm, including sports related.

It is important to check your levels regularly if you supplement your dietary magnesium.  In some instances it is also indicated to have an EKG since some type of heart blocks can be worsened by magnesium intake.

Source for study: "Dietary Magnesium Usual Intake is Associated with Favorable Diabetes-Related Physiological Outcomes and Reduced Risk of Metabolic Syndrome: An NHANES 2001-2010 Analysis," at http://www.jscimedcentral.com/Nutrition/nutrition-2-1038.pdf. Study authors include Yanni Papanikolaou, Nutritional Strategies, Inc.; James Brooks, Pharmavite, LLC; Carroll Reider, Pharmavite, LLC; and Victor L. Fulgoni, III, Nutrition Impact, LLC.

May 21, 2015

New research shows that melatonin may contibute to postmenopausal weight gain. Based on previous research, it was indicated that melatonin secretion decreases as we age, showing a significant decline in women after the age of 40.

The investigators concluded, "The obtained results indicate a significant effect of melatonin deficiency on the process of weight gain in postmenopausal women and justify its use in treatment of these disorders."

Reference: Walecka-Kapica E, et al. Int J Mol Sci. 2015;16:1030-42.

Melatoninn levels are easily measured, usually in urine.  Use a high quality supplement to ensure you take the stated amount of melatonin.  Long use of high quantities might lead to decrease serotonin so caution is advised.

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